Abstract:By using the ERA-Interim reanalysis data of ECMWF, the evolution of circulation field, geopotential height and vorticity of typhoon was analyzed, the development process was obtained. Based on the above, the distribution characteristics of substances (cloud cover, ozone, cloud ice, water vapor) in Tropical Tropopause Layer(TTL) region were also analyzed, and its possible reasons were explored. Results show that:(1) The ozone concentration of the TTL region(abundant typhoon activity) is relatively lower. (2)The cloud ice and water vapor concentrations increase in the TTL region during the typhoon period, whose concentration centers locate around the typhoon center. (3) The typhoon activity contributes to the increasing of cloud cover in TTL region, there is an extreme value. (4) Vertical upward movement caused by the typhoon results in the stratosphere-troposphere exchange, and thus has a major impact on the distribution of trace substances in the TTL region.